Research Summary

Selected Publications

• 1. Okawa Y, Sasagawa S, Johnson TA, Kato H, Nagaoka K, Kobayashi Y, Hayashi A, Shibayama T, Maejima K, Tanaka H, Miyano S, Shibahara J, Nishizuka SS, Hirano S, Seto Y, Iwaya T, Kakimi K, Yasuda T, and Nakagawa H.:
  "Immuno-genomic analysis reveals eosinophilic feature and favorable prognosis of female non-smoking esophageal squamous cell carcinomas."
  Cancer Letters. 581:216499 (2024)
• 2. Wang H, Chen L, Xue R, Lie M, Bai J, Bao J, Wang Y, Li Z, Wang W, Wang R, Zheng B, Yang A, Hu J, Lie K, Shen S, Wang Y, Zhu Y, Gu J, Gao D, Wng XW, Nakagawa H, Zang N, Wu L, Rozen SG, Bai F, and Wang H.:
  "Deep whole genome analysis of 494 hepatocellular carcinomas."
  Nature. 627(8004):586-593 (2024)
• 3. Okawa Y, Iwasaki Y, Johnson TA, Ebata N, Inai C, Endo M, Maejima K, Sasagawa S,　Fujita M, Matsuda K, Murakami Y, Nakamura T, Hirano S, Momozawa Y and Nakagawa H.:
  "Hereditary cancer variants and homologous recombination deficiency in biliary tract cancers."
  J Hepatol. 78(2):333-342 (2023)
• 4. Shima Y, Sasagawa S, Ohta N, Oyama R, Sogawa C, Kim Y, Sakashita-Kubota M, Kawakami H, Naemura K, Takubo N, Kobayashi M, Ozeki A, Nakaki R, Tanaka M, Kamatani Y, Matsuda K, Kurihara H, Furihata T, Takahashi S, Rikitake Y, Kozaki K, Nakafuku M, Mataga N, Ohtsuka N, Akimitsu N, Wada Y, Kamiguchi H, Okabe S, Kato T, Nakagawa H, Saito N, and Nakatomi H.:
  "Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms."
  Science Trans Med. 15(700):eabq77218 (2023)
• 5. Fujita M, Chen MM, Siwak DR, Sasagawa S, Arihiro M, Arihiro K, Ono A, Miura R, Osawa-Tatsuguchi A,　Maejima K, Aikata H, Ueno M, Hayami S, Yamaue H, Chayama K, Lu Y, Liang H, Nishizuka SS, and Nakagawa H.:
  "Proteogenomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets."
  Nat Commun. 13(1):6481 (2022)
• 6. Sasagawa S, Kato H, Nagaoka K, Sun C, Imano M, Sato T, Johnson TA, Fujita M, Maejima K, Okawa Y, Kakimi K, Yasuda T, and Nakagawa H.:
  "Immuno-genomic profiling of biopsy specimens predicts neoadjuvant chemotherapy response in esophageal squamous cell carcinoma."
  Cell Rep Med. 3(8):100705 (2022)
• 7. The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium.:
  "Pan-cancer analysis of whole genomes."
  Nature 578(7793):82-93 (2020)
• 8. Fujimoto A, Fujita M, Maejima K, Hasegawa T, Nakano K, Oku-Sasaki A, Wong J, Shiraishi Y, Miyano S, Imoto S, Akagi T, and Nakagawa H.:
  "Comprehensive analysis of indels in whole-genome microsatellite regions and microsatellite instability across 21 cancer types."
  Genome Res. 30: 334-346 (2020)
• 9. Takata　R, Takahashi A, Fujita M, Momozawa Y, Saunders EJ, Yamada H, Maejima K, Nakano K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Sasaki M, Shimizu A, Tanno K, Minegishi N, Suzuki K, Matsuda K, Kubo K, Inazawa J, Egawa S, Haiman CA, Ogawa O, Obara W, Kamatani Y, Akamatsu S, and Nakagawa H.:
  "12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population."
  Nat Commun. 10:4422 (2019)
• 10. Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, Tanaka H, Taniguchi H, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Wardell CP, Hayami S, Nakamura T, Aikata H, Arihiro K, Boroevich KA, Abe T, Nakano N, Maejima K, Sasaki-Oku A, Ohsawa A, Shibuya T, Nakamura H, Hama N, Hosoda F, Arai Y, Ohashi S, Urushidate T, Nagae G, Yamamoto S, Ueda H, Tatsuno K, Ojima H, Hiraoka N, Okusaka T, Kubo M, Marubashi S, Yamada T, Hirano S, Yamamoto M, Ohdan H, Shimada K, Ishikawa O, Yamaue H, Chayama K, Miyano S, Aburatani H, Shibata T, and Nakagawa H.:
  "Whole genome mutational landscape and characterization of non-coding and structural mutations in liver cancer."
  Nat Genet 48: 500-509 (2016)

Recent Research Results

• 

  Jul. 1, 2016
  Liver cancer’s genomic landscape

• 

  Apr. 17, 2015
  An infectious imprint on liver cancer

• 

  Jan. 30, 2015
  Hot on the trail of the hepatitis-liver cancer connection

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