Research Summary

Selected Publications

• 1.Chamoto K, Chowdhury PS, Kumar A, Sonomura K, Matsuda F, Fagarasan S, Honjo T.
  "Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity."
  Proc Natl Acad Sci U S A. 114(5):E761-E770 (2017)
• 2.Zhang B, Chikuma S, Hori S, Fagarasan S, Honjo T.
  "Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model."
  Proc Natl Acad Sci U S A, 113(30):8490-5 (2016)
• 3.Sutherland DB, Suzuki K, Fagarasan S.
  "Fostering of advanced mutualism with gut microbiota by Immunoglobulin A."
  Immunol Rev., 270(1), 20-31 (2016)
• 4.Kawamoto S, Maruya M, Kato LM, Suda W, Atarashi K, Doi Y, Tsutsui Y, Qin H, Honda K, Okada T, Hattori M, Fagarasan S.:
  "Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis."
  Immunity, 41(1), 152-65 (2014)
• 5.Kawamoto S, Tran TH, Maruya M, Suzuki K, Doi Y, Tsutsui Y, Kato LM, Fagarasan S.:
  "The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut."
  Science, 336(6080), 485-9 (2012).
• 6.Suzuki K, Maruya M, Kawamoto S, Sitnik K, Kitamura H, Agace WW, Fagarasan S.:
  "The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut."
  Immunity, 33:71-83 (2010)
• 7.Fagarasan S, Kawamoto S, Kanagawa O, Suzuki K.:
  "Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis."
  Annu. Rev. Immunol. 28:243-273. (2010)
• 8.Tsuji M, Komatsu N, Kawamoto S, Suzuki K, Kanagawa O, Honjo T, Hori S, Fagarasan S.
  "Preferential generation of follicular B helper T (T_FH) cells from Foxp3⁺ T cells in gut Peyer's patches."
  Science, 323:1488-1492 (2009).
• 9.Suzuki, K., Meek, B., Doi, Y., Muramatsu, M., Chiba, T., Honjo, T., and Fagarasan, S.:
  "Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut"
  Proc. Natl. Acad. Sci. USA, 101, 1981-1986 (2004)
• 10.Fagarasan, S., Muramatsu, M., Suzuki, K., Nagaoka, H., Hiai, H., and Honjo, T.:
  "Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora"
  Science, Nov 15, 298 (5597), 1424-7 (2002).

Recent Research Results

• 

  Nov. 25, 2021
  GABA released by B-cells blunts the immune response to tumors

• 

  Mar. 30, 2018
  Anxiety is infectious

• 

  Oct. 24, 2017
  Activation of immune T cells leads to behavioral changes

• 

  Aug. 22, 2014
  A gut feeling on bacterial diversity

• 

  Jul. 11, 2014
  In the gut, immunity is a two-way street

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