Research Summary

Selected Publications

• 1. Takeuchi T, Miyauchi E, Kanaya T, Kato T, Nakanishi Y, Watanabe T, Kitami T, Taida T, Sasaki T, Negishi H, Shimamoto S, Matsuyama A, Kimura I, Williams IR,Ohara O, Ohno H.:
  "Acetate differentially regulates IgA reactivity to commensal bacteria."
  Nature 595(7868):560-564, 2021.
• 2. Miyauchi E, Kim S-W, Suda W, Kawasumi M, Onawa S, Taguchi-Atarashi N, Morita M, Taylor TD, Hattori M, Ohno H.:
  "Gut microbes act in concert to exacerbate inflammation in spinal cords."
  Nature 585(7823): 102-106, 2020.
• 3. Satoh-Takayama N, Kato T, Motomura Y, Kageyama T, Taguchi-Atarashi N, Kinoshita-Daitoku R, Kuroda E, Di Santo JP, Mimuro H, Moro K, Ohno H.:
  "Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA."
  Immunity 52(4):635-649.e4, 2020.
• 4. Tamaura M, Satoh-Takayama N, Tsumura M, Sasaki T, Goda S, Kageyama T, Hayakawa S, Kimura S, Asano T, Nakayama M, Koseki H, Ohara O, 7, Okada S, Ohno H, Kobayashi M.:
  "Human Gain-of-Function STAT1 Mutation disturbs IL-17 Immunity in Mice."
  Int Immunol 32(4):259-272, 2020.
• 5. Hara S, Sasaki T, Satoh-Takayama N, Kanaya T, Kato T, Takikawa Y, Takahashi M, Tachibana N, Kim KS, Surh CD, Ohno H.:
  "Dietary Antigens Induce Germinal Center Responses in Peyer's Patches and Antigen-Specific IgA Production."
  Front Immunol. 10:2432, 2019.
• 6. Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R., Ohno, H.:
  "Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-kB signaling."
  J. Exp. Med. 215:501-519, 2018.
• 7. Date Y, Ebisawa M, Fukuda S, Shima H, Obata Y, Takahashi D, Kato T, Hanazato M, Nakato G, Williams IR, Hase K, Ohno H.:
  "NALT M cells are important for immune induction for the common mucosal immune system."
  Int. Immunol. 29(10): 471-478, 2017.
• 8. Yanagihara S, Kanaya T, Fukuda S, Nakato G, Hanazato M, Wu XR, Yamamoto N, Ohno H.:
  "Uromodulin-SlpA binding dictates Lactobacillus acidophilus uptake by intestinal epithelial M cells."
  Int. Immunol. 29: 357-363, 2017.
• 9. Shimokawa, C., Kanaya, T., Hachisuka, M., Ishiwata, K., Hisaeda, H., Kurashima, Y., Kiyono, H., Yoshimoto, T., Kaisho, T., Ohno, H.:
  "Mast cells are crucial for induction of group 2 innate lymphoid cells and clearance of helminth infections."
  Immunity 46: 863-874, 2017.
• 10. Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H., Ohno, H.:
  "IL-22BP dictates characteristics of Peyer’s patch follicle-associated epithelium for antigen uptake."
  J. Exp. Med. 163(2): 367-380, 2017.

Recent Research Results

• 

  Aug. 22, 2022
  How a Japanese herbal medicine protects the gut against inflammatory bowel disease

• 

  Jul. 20, 2021
  A simple compound to control complex gut microbes

• 

  Aug. 27, 2020
  Tag team gut bacteria worsen symptoms of multiple sclerosis

• 

  Jun. 26, 2020
  Friendly bacteria fight stomach ulcers

• 

  Jul. 3, 2019
  Innate immune responses to high-fat diets lead to obesity

• 

  Aug. 10, 2017
  The mast-er of worm defense

• Jan. 10, 2014
  Friends in low places preserve gut health

• 

  Nov. 14, 2013
  Fatty acid produced by gut bacteria boosts the immune system

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