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革新知能統合研究センター 病理情報学チーム

チームリーダー 山本 陽一朗(M.D., Ph.D.)


山本 陽一朗 (M.D., Ph.D.)


  • AIを用いた新規疾患メカニズムや治療法の発見
  • 最適な治療法の選択
  • 医学データの統合的解析


  • 学際研究


  • 分子生物 & 遺伝学
  • 臨床医学
  • コンピューター科学
  • 数学



  • 1.Yamamoto Y, Saito A, Tateishi A, Shimojo H, Kanno H, Tsuchiya S, Ito KI, Cosatto E, Graf HP, Moraleda RR, Eils R, and Grabe N.:
    "Quantitative diagnosis of breast tumors by morphometric classification of microenvironmental myoepithelial cells using a machine learning approach."
    Sci Rep. 7, 46732 (2017).
  • 2.*Yamamoto Y, Offord CP, Kimura G, Kuribayashi S, Takeda H, Tsuchiya S, Shimojo H, Kanno H, Bozic I, Nowak MA, Bajzer ž, and Dingli D.:
    "Tumor and immune cell dynamics explain the PSA bounce after prostate cancer brachytherapy."
    Br J Cancer. 115, 195–202 (2016).
  • 3.*Saito A, Numata Y, Hamada T, Horisawa T, Cosatto E, Graf HP, Kuroda M, and Yamamoto Y.:
    "A novel method for morphological pleomorphism and heterogeneity quantitative measurement: Named cell feature level co-occurrence matrix."
    J Pathol Inform. 7, 36 (2016).
  • 4.*Yamada M, Saito A, Yamamoto Y, Cosatto E, Kurata A, Nagao T, Tateishi A, and Kuroda M.:
    "Quantitative nucleic features are effective for discrimination of intraductal proliferative lesions of the breast."
    J Pathol Inform. 7, 1 (2016).
  • 5.*Ogura M, Yamamoto Y, Miyashita H, Kumamoto H, and Fukumoto M.:
    "Quantitative analysis of nuclear shape in oral squamous cell carcinoma is useful for predicting the chemotherapeutic response."
    Med Mol Morphol. 49, 76-82 (2015).
  • 6.*Yamamoto Y, Oguro T, Mieda J, Ohashi R, Tsuchiya S:
    "In situ search for breast cancer stem cells and their niche: the film sheet epoxy resin embedding method and breast cancer stem cells (Abstract of the 2011th Maruyama Memorial Lectures)."
    J Nippon Med Sch. 80, 240-241 (2013).
  • 7.*Yamamoto Y, Yamamoto Y, Marugame A, Ogura M, Saito A, Ohta K, Fukumoto M, and Murata T.:
    "Age-related decrease of the retinal vasculature area evaluated by a novel computer-aided analysis system."
    Tohoku J Exp Med. 228, 229-237 (2012).
  • 8.*Yamamoto Y, Usuda N, Oghiso Y, Kuwahara Y, and Fukumoto M.:
    "The uneven irradiation of a target cell and its dynamic movement can mathematically explain incubation period for the induction of cancer by internally deposited radionuclides."
    Health Phys. 99, 388-393 (2010).
  • 9.*Yamamoto Y, Chikawa J, Uegaki Y, Usuda N, Kuwahara Y, and Fukumoto M.:
    "Histological type of Thorotrast-induced liver tumors associated with the translocation of deposited radionuclides."
    Cancer Sci. 101, 336-340 (2010).
  • 10.*Yamamoto Y, Usuda N, Takatsuji T, Kuwahara Y, and Fukumoto M.:
    "Long incubation period for the induction of cancer by Thorotrast is attributed to the uneven irradiation of liver cells at the microscopic level."
    Radiat Res. 171, 494-503 (2009).




  • 2016年9月19日:日本経済新聞掲載 "がん細胞、AIで画像判定"
  • 研究紹介:文部科学省科学研究費新学術領域研究 がん研究分野の特性等を踏まえた支援活動



山本 陽一朗


〒103-0027 東京都中央区日本橋1-4-1 日本橋一丁目三井ビルディング 15階
Email: yoichiro.yamamoto [at] riken.jp