研究概要

主要論文

• 1.Shirai T, Osanai T, Kondo A.
  "Designing intracellular metabolism for production of target compounds by introducing a heterologous metabolic reaction based on a Synechosystis sp. 6803 genome-scale model."
  Microb Cell Fact. 2016 Jan 18;15:13. doi: 10.1186/s12934-016-0416-8.
• 2.Noda S, Shirai T, Oyama S, Kondo A.:
  "Metabolic design of a platform Escherichia coli strain producing various chorismate derivatives."
  Metab Eng. 33:119-29. doi: 10.1016/j.ymben.2015.11.007. (2016)
• 3.Osanai T, Shirai T, Iijima H, Nakaya Y, Okamoto M, Kondo A, Hirai MY.:
  "Genetic manipulation of a metabolic enzyme and a transcriptional regulator increasing succinate excretion from unicellular cyanobacterium."
  Front Microbiol. 6, doi: 10.3389/fmicb.2015.01064. (2015)
• 4.Iijima H, Shirai T, Okamoto M, Kondo A, Hirai MY, Osanai T.:
  "Changes in primary metabolism under light and dark conditions in response to overproduction of a response regulator RpaA in the unicellular cyanobacterium Synechocystis sp. PCC 6803."
  Front Microbiol. 6, doi: 10.3389/fmicb.2015.00888. (2015)
• 5.Sasaki K, Okamoto M, Shirai T, Tsuge Y, Teramura H, Sasaki D, Kawaguchi H, Hasunuma T, Ogino C, Matsuda F, Kikuchi J, Kondo A.:
  "Precipitate obtained following membrane separation of hydrothermally pretreated rice straw liquid revealed by 2D NMR to have high lignin content."
  Biotechnol Biofuels. 8 doi: 10.1186/s13068-015-0273-4. (2015)
• 6.Noda S, Shirai T, Mochida K, Matsuda F, Oyama S, Okamoto M, Kondo A.:
  "Evaluation of Brachypodium distachyon L-Tyrosine Decarboxylase Using L-Tyrosine Over-Producing Saccharomyces cerevisiae."
  PLoS One. 21, e0125488 (2015).
• 7.Noda, S., Kawai, Y., Tanaka, T., Kondo, A.:
  "4-Vinylphenol biosynthesis from cellulose as the sole carbon source using phenolic acid decarboxylase-and tyrosine ammonia lyase-expressing Streptomyces lividans."
  Bioresour Technol, 180, 59-65. (2015)
• 8.Noda, S., Matsumoto, T., Tanaka, T., Kondo, A.:
  "Secretory production of tetrameric native full-length streptavidin with thermostability using Streptomyces lividans as a host."
  Microb Cell Fact, 14, 5 (2015)
• 9.Osanai T, Shirai T, Iijima H, Kuwahara A, Suzuki I, Kondo A, Hirai MY.:
  "Alteration of cyanobacterial sugar and amino acid metabolism by overexpression hik8, encoding a KaiC-associated histidine kinase."
  Environ Microbiol. 17, 2430-2340. (2015)
• 10.Shirai T, Matsuda F, Okamoto M, Kondo A.:
  "Evaluation of control mechanisms for Saccharomyces cerevisiae central metabolic reactions using metabolome data of eight single-gene deletion mutants."
  Appl Microbiol Biotechnol. 97, 3569-3577. (2013)

研究成果（プレスリリース）

• 

  2023年1月10日
  光合成が始まる瞬間の代謝機構を解明

• 

  2022年3月9日
  常識を覆す糖の再排出メカニズムの発見

• 

  2021年4月13日
  ブタジエンのバイオ生産に初成功

• 

  2017年10月27日
  大腸菌を用いたマレイン酸合成法の開発

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