研究概要

主要論文

• 1. Takizawa, N., Ogura, Y., Fujita, Y., Noda, T., Shigematsu, H., Hayashi, T., Kurokawa, K.:
  "Local structural changes of the influenza A virus ribonucleoprotein complex by single mutations in the specific residues involved in efficient genome packaging"
  Virology 531, 126-140, (2019)
• 2. Hanawa-Suetsugu, K., Itoh, Y., Ab Fatah, M., Nishimura, T., Takemura, K., Takeshita, K., Kubota, S., Miyazaki, N., Wan Mohamad Noor, WNI., Inaba, T., Nguyen, NTH., Hamada-Nakahara, S., Oono-Yakura, K., Tachikawa, M., Iwasaki, K., Kohda, D., Yamamoto, M., Kitao, A., Shimada, A. and Suetsugu, S.:
  "Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7"
  Nature Communications10, 4763 (2019)
• 3. Shigematsu, H., Imasaki, T., Doki, C., Sumi, T., Aoki, M., Uchikubo-Kamo, T., Sakamoto, A., Tokuraku, K., Shirouzu, M. and Nitta, R.:
  "Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs"
  Journal of Cell Biology 217 (12), 4155-4163 (2018)
• 4. Yamamoto, M., Hirata, K., Yamashita, K., Hasegawa, K., Ueno, G., Ago, H., and Kumasaka, T.:
  "Protein microcrystallography using synchrotron radiation"
  IUCrJ 4 (5), 529-539 (2017)
• 5. M Suga, F Akita, M Sugahara, M Kubo, Y Nakajima, T Nakane, K Yamashita, Y Umena, M Nakabayashi, T Yamane, T Nakano, M Suzuk, T Masuda, S Inoue, T Kimura, T Nomura, S Yonekura, L-J Yu, T Sakamoto, T Motomura, J-H Chen, Y Kato1, T Noguchi, K Tono, Y Joti, T Kameshima, T Hatsui, E Nango, R Tanaka, H Naitow, Y Matsuura, A Yamashita, M Yamamoto, O Nureki, M Yabashi, T Ishikawa, S Iwata, J-R Shen.:
  "Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL"
  Nature 543(7643):131-135 (2017)
• 6. Matsumoto, S., Miyano, N., Baba, S., Liao, J., Kawamura, T., Tsuda, C., Takeda A,, Yamamoto, M., Kumasaka, T., Kataoka, T. and Shima, F.:
  "Molecular Mechanism for Conformational Dynamics of Ras・GTP Elucidated from In-Situ Structural Transition in Crystal"
  Scientific Report 6, 25931 (2016)
• 7. Deng, D, Sun, PC, Yan, CY, Ke, M, Jiang, X, Xiong, L, Ren, WL, Hirata, K, Yamamoto, M, Fan, SL and Yan, N.:
  "Molecular basis of ligand recognition and transport by glucose transporters"
  Nature 526 (7573), 391-396.(2015)
• 8. Tanabe, H, Fujii, Y, Okada-Iwabu, M, Iwabu, M, Nakamura, Y, Hosaka, T, Motoyama, K, Ikeda, M, Wakiyama, M, Terada, T, Ohsawa, N, Hato, M, Ogasawara, S, Hino, T, Murata, T, Iwata, S, Hirata, K, Kawano, Y, Yamamoto, M, Kimura-Someya, T, Shirouzu, M, Yamauchi, T, Kadowaki, T, and Yokoyama,S.:
  "Crystal structures of the human adiponectin receptors"
  Nature 520 (7547), 312-316 (2015)
• 9. Shima, F, Yoshikawa, Y., Ye, M., Araki, M, Matsumoto, S., Liao, JL., Hu, LZ., Sugimoto, T ., Ijiri, Y., Takeda, A., Nishiyama, Y., Sato, C., Muraoka, S.,Tamura, A., Osoda, T., Tsuda, K., Miyakawa, T., Fukunishi, H., Shimada, J., Kumasaka, T., Yamamoto, M., Kataoka, T.:
  "In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction"
  Proc. Nat. Acad. Sci the USA 110, 8182-8187 (2013)
• 10. Smith, JL., Fischetti RF. and Yamamoto, M.:
  "Micro-crystallography comes of age"
  Current Opinion in Structural Biology 22, 602-612 (2012)

研究成果（プレスリリース）

• 

  2022年5月24日
  胃酸抑制剤の結合構造を解析

• 

  2022年3月3日
  酵素の機能改変で自然界にないイソプレノイドを合成

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募集職種	応募締切
研究員または特別研究員募集（C21-0102）	ポストが決まり次第

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