研究概要

主要論文

「*」は、理研外のみでの成果です。

• 1. Quek, L.E., Krycer, J.R., Ohno, S., Yugi, K., Fazakerley, D.J., Scalzo, R., Elkington, S.D., Dai, Z,, Hirayama, A., Ikeda, S., Shoji, F., Suzuki, K., Locasale, J.W., Soga, T., James, D.E., and Kuroda, S.:
  "Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin"
  iScience 23(2), 100855 (2020).
• 2. Yugi, K., Ohno, S., Krycer, J.R., James, D.E., and Kuroda, S.:
  "Rate-oriented trans-omics: integration of multiple omic data on the basis of reaction kinetics"
  Curr. Opin. Syst. Biol. 15, 109-120 (2019).
• 3. †Kawata, K., †Hatano, A., †Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K.Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K.I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T., and Kuroda, S.:
  "Trans-omic analysis reveals selective responses to induced and basal insulin across signaling, transcriptional, and metabolic networks"
  iScience 7, 212-229 (2018) (Cover Article; † These authors contributed equally).
• 4. Yugi, K., and Kuroda, S.:
  "Metabolism as a signal generator across trans-omic networks at distinct time scales"
  Curr. Opin. Syst. Biol. 8, 59-66 (2018).
• 5. †Krycer, J.R., †Yugi, K., Hirayama, A., Fazakerley, D.J., Quek, L.E., Scalzo, R., Ohno, S., Hodson, M.P., Ikeda, S., Soji, F., Suzuki, K., Domanova, W., Parker, B.K., Nelson, M.E., Humphrey, S.J., Turner, N., Hoehn, K.L., Cooney, G.J., Soga, T., Kuroda, S., and James, D.E.:
  "Dynamic metabolomics reveals that insulin primes the adipocyte for glucose metabolism"
  Cell Rep. 21(12), 3536-3547 (2017) († These authors contributed equally).
• 6. Yugi, K., and Kuroda, S.:
  "Metabolism-Centric Trans-Omics"
  Cell Syst. 4(1), 19-20 (2017).
• 7. *Yugi, K., Kubota, H., Hatano, A., and Kuroda, S.:
  "Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple ‘Omic’ Layers"
  Trends Biotechnol. 34(4), 276-290 (2016) (Cover Article).
• 8. *†Yugi, K., †Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K.I., Kashikura, K., Endo, K., Ikeda, K., Soga, T., and Kuroda, S.:
  "Reconstruction of insulin signal flow from phosphoproteome and metabolome data"
  Cell Rep. 8(4), 1171-1183 (2014) († These authors contributed equally).
• 9. *Noguchi, R., Kubota, H., Yugi, K., Toyoshima, Y., Komori, Y., Soga, T., and Kuroda, S.:
  "The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns"
  Mol. Syst. Biol. 9, 664 (2013).
• 10. *Ishii, N., Nakahigashi, K., Baba, T., Robert, M., Soga, T., Kanai, A., Hirasawa, T., Naba, M., Hirai, K., Hoque, A., Ho, P.Y., Kakazu, Y., Sugawara, K., Igarashi, S., Harada, S., Masuda, T., Sugiyama, N., Togashi, T., Hasegawa, M., Takai, Y., Yugi, K., Arakawa, K., Iwata, N., Toya, Y., Nakayama, Y., Nishioka, T., Shimizu, K., Mori, H., and Tomita, M.:
  "Multiple high-throughput analyses monitor the response of E. coli to perturbations"
  Science 316(5824), 593-7 (2007).

研究成果（プレスリリース）

• 

  2024年2月19日
  細胞内の多階層ネットワークの可視化技術を開発

• 

  2022年3月22日
  脂質代謝の遺伝子回路を公開情報から再構築

• 

  2018年9月11日
  トランスオミクス解析による高濃度と低濃度のインスリン作用の選択性の解明

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募集職種	応募締切
研究員または特別研究員募集（IMS408-2202）	ポストが決まり次第

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