研究概要

主要論文

• 1. Fukuda K., Shimura C., Miura H., et al.:
  "Regulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases."
  Commun Biol 4:571 (2021)
• 2. Poonperm R. and Hiratani I.:
  "Formation of a multi-layered 3-dimensional structure of the heterochromatin compartment during early mammalian development."
  Dev Growth Differ 63:5-17 (2021)
• 3. Miura H., Takahashi S., Shibata T., et al.:
  "Mapping replication timing domains genome wide in single mammalian cells with single-cell DNA replication sequencing."
  Nat Protoc 15:4058-4100 (2020)
• 4. Kadota M., Nishimura O., Miura H., et al.:
  "Multifaceted Hi-C benchmarking: what makes a difference in chromosome-scale genome scaffolding?"
  Gigascience 9:giz158 (2020)
• 5. Abdalla M.O.A., Yamamoto T., Maehara K., et al.:
  "The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis."
  Nat Commun 10:3778 (2019)
• 6. Miura H., Takahashi S., Poonperm R., et al.:
  "Single-cell DNA replication profiling identifies spatiotemporal developmental dynamics of chromosome organization."
  Nat Genet 51:1356-1368 (2019)
• 7. Hiratani I. and Takahashi S.:
  "DNA replication timing enters the single-cell era."
  Genes 10:221 (2019)
• 8. Takahashi S., Miura H., Shibata T., et al.:
  "Genome-wide stability of the DNA replication program in single mammalian cells."
  Nat Genet 51:529-540 (2019)
• 9. Miura H., Poonperm R., Takahashi S., et al.:
  "Practical analysis of Hi-C data: generating A/B compartment profiles."
  Methods Mol Biol 1861:221-245 (2018)
• 10. Takahashi S., Kobayashi S., Hiratani I.:
  "Epigenetic differences between naïve and primed pluripotent cells."
  Cell Mol Life Sci 75:1191-1203 (2018)

研究成果（プレスリリース）

• 

  2019年8月22日
  ゲノムDNAの立体構造から見えた乳がん細胞の弱点

• 

  2019年8月13日
  染色体の形は細胞分化と共にこう変わる

• 

  2019年2月26日
  ゲノムDNA複製の真の姿を捉えた

刊行物