研究概要

研究テーマ

• アレルギー疾患関連遺伝子解析
• 呼吸器疾患関連遺伝子解析

主要論文

• 1.Park, H.W., Dahlin, A., Tse, S., Duan, Q.L., Schuemann, B., Martinez, F.D., Peters, S.P., Szefler, S.J., Lima, J.J., Kubo, M., Tamari, M., and Tantisira, K.G.:
  "Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids"
  J Allergy Clin Immunol 133, 664-669 (2014).
• 2.Ellinghaus, D., Baurecht, H., Esparza-Gordillo, J., Rodríguez, E., Matanovic, A., Marenholz, I., Hübner, N., Schaarschmidt, H., Novak, N., Michel, S., Maintz, L., Werfel, T., Meyer-Hoffert, U., Hotze, M., Prokisch, H., Heim, K., Herder, C., Hirota, T., Tamari, M., Kubo, M., Takahashi, A., Nakamura, Y., Tsoi, L.C., Stuart, P., Elder, J.T., Sun, L., Zuo, X., Yang, S., Zhang, X., Hoffmann, P., Nöthen, M.M., Fölster-Holst, R., Winkelmann, J., Illig, T., Boehm, B.O., Duerr, R.H., Büning, C., Brand, S., Glas, J., McAleer, M.A., Fahy, C.M., Kabesch, M., Brown, S., McLean, W.H., Irvine, A.D., Schreiber, S., Lee, Y.A., Franke, A., and Weidinger, S.:
  "High-density genotyping study identifies four new susceptibility loci for atopic dermatitis"
  Nat Genet 45, 808-812 (2013).
• 3.Tomita, K., Sakashita, M., Hirota, T., Tanaka, S., Masuyama, K., Yamada, T., Fujieda, S., Miyatake, A., Hizawa, N., Kubo, M., Nakamura, Y., and Tamari, M.:
  "Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population"
  Allergy 68, 92-100 (2013).
• 4.Hirota, T., Takahashi, A., Kubo, M., Tsunoda, T., Tomita, K., Sakashita, M., Yamada, T., Fujieda, S., Tanaka, S., Doi, S., Miyatake, A., Enomoto, T., Nishiyama, C., Nakano, N., Maeda, K., Okumura, K., Ogawa, H., Ikeda, S., Noguchi, E., Sakamoto, T., Hizawa, N., Ebe, K., Saeki, H., Sasaki, T., Ebihara, T., Amagai, M., Takeuchi, S., Furue, M., Nakamura, Y., and Tamari, M.:
  "Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population"
  Nat Genet 44, 1222-1226 (2012).
• 5.Tantisira, K.G., Lasky-Su, J., Harada, M., Murphy, A., Litonjua, A.A., Himes, B.E., Lange, C., Lazarus, R., Sylvia, J., Klanderman, B., Duan, Q.L., Qiu, W., Hirota, T., Martinez, F.D., Mauger, D., Sorkness, C., Szefler, S., Lazarus, S.C., Lemanske, R.F. Jr, Peters, S.P., Lima, J.J., Nakamura, Y., Tamari, M., and Weiss, S.T.:
  "Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma"
  N Engl J Med 365, 1173-1183 (2011).
• 6.Hirota, T., Takahashi, A., Kubo, M., Tsunoda, T., Tomita, K., Doi, S., Fujita, K., Miyatake, A., Enomoto, T., Miyagawa, T., Adachi, M., Tanaka, H., Niimi, A., Matsumoto, H., Ito, I., Masuko, H., Sakamoto, T., Hizawa, N., Taniguchi, M., Lima, J.J., Irvin, C.G., Peters, S.P., Himes, B.E., Litonjua, A.A., Tantisira, K.G., Weiss, S.T., Kamatani, N., Nakamura, Y., and Tamari, M.:
  "Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population"
  Nat Genet 43, 893-896 (2011).
• 7.Harada, M., Hirota, T., Jodo, A.I., Hitomi, Y., Sakashita, M., Tsunoda, T., Miyagawa, T., Doi, S., Kameda, M., Fujita, K., Miyatake, A., Enomoto, T., Noguchi, E., Masuko, H., Sakamoto, T., Hizawa, N., Suzuki, Y., Yoshihara, S., Adachi, M., Ebisawa, M., Saito, H., Matsumoto, K., Nakajima, T., Mathias, R.A., Rafaels, N., Barnes, K.C., Himes, B.E., Duan, Q.L., Tantisira, K.G., Weiss, S.T., Nakamura, Y., Ziegler, S.F., and Tamari, M.:
  "Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma"
  Am J Respir Cell Mol Biol 44, 787-793 (2011).
• 8.Hitomi, Y., Ebisawa, M., Tomikawa, M., Imai, T., Komata, T., Hirota, T., Harada, M., Sakashita, M., Suzuki, Y., Shimojo, N., Kohno, Y., Fujita, K., Miyatake, A., Doi, S., Enomoto, T., Taniguchi, M., Higashi, N., Nakamura, Y., and Tamari, M.:
  "Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma"
  J Allergy Clin Immunol 124, 779-785 (2009).
• 9.Harada, M., Obara, K., Hirota, T., Yoshimoto, T., Hitomi, Y., Sakashita, M., Doi, S., Miyatake, A., Fujita, K., Enomoto, T., Taniguchi, M., Higashi, N., Fukutomi, Y., Nakanishi, K., Nakamura, Y., and Tamari, M.:
  "A functional polymorphism in IL-18 is associated with severity of bronchial asthma"
  Am J Respir Crit Care Med 180, 1048-1055 (2009).
• 10.Hirota, T., Harada,M., Sakashita, M., Doi, S., Miyatake, A., Fujita, K., Enomoto, T., Ebisawa, M., Yoshihara, S., Noguchi, E., Saito, H., Nakamura, Y., and Tamari M.:
  "Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population"
  J Allergy Clin Immunol 121, 769-770 (2008).

研究成果（プレスリリース）

• 

  2013年6月11日
  アトピー性皮膚炎の発症に関わる4つのゲノム領域を新たに発見

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採用情報

募集職種	応募締切
チームリーダー募集（IMS701-2002）	2020年11月30日

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