研究概要

主要論文

「*」は、理研外のみでの成果です。

• 1. Ishigaki K, Sakaue S, Terao C, Luo Y, Sonehara K, Yamaguchi K, Amariuta T, Too CL, Laufer VA, Scott IC, Viatte S, Takahashi M, Ohmura K, Murasawa A, Hashimoto M, Ito H, Hammoudeh M, Emadi SA, Masri BK, Halabi H, Badsha H, Uthman IW, Wu X, Lin L, Li T, Plant D, Barton A, Orozco G, Verstappen SMM, Bowes J, MacGregor AJ, Honda S, Koido M, Tomizuka K, Kamatani Y, Tanaka H, Tanaka E, Suzuki A, Maeda Y, Yamamoto K, Miyawaki S, Xie G, Zhang J, Amos CI, Keystone E, Wolbink G, van der Horst-Bruinsma I, Cui J, Liao KP, Carroll RJ, Lee HS, Bang SY, Siminovitch KA, de Vries N, Alfredsson L, Rantapää-Dahlqvist S, Karlson EW, Bae SC, Kimberly RP, Edberg JC, Mariette X, Huizinga T, Dieudé P, Schneider M, Kerick M, Denny JC; BioBank Japan Project; Matsuda K, Matsuo K, Mimori T, Matsuda F, Fujio K, Tanaka Y, Kumanogoh A, Traylor M, Lewis CM, Eyre S, Xu H, Saxena R, Arayssi T, Kochi Y, Ikari K, Harigai M, Gregersen PK, Yamamoto K, Louis Bridges S Jr, Padyukov L, Martin J, Klareskog L, Okada Y, Raychaudhuri S.
  "Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis."
  Nature Genetics. 54(11):1640-1651 (2022)
• 2. *Ishigaki K, Lagattuta KA, Luo Y, James EA, Buckner JH, Raychaudhuri S.
  "HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors."
  Nature Genetics. 54(4):393-402 (2022)
• 3. Nakano M, Ota M, Takeshima Y, Iwasaki Y, Hatano H, Nagafuchi Y, Itamiya T, Maeda J, Yoshida R, Yamada S, Nishiwaki A, Takahashi H, Takahashi H, Akutsu Y, Kusuda T, Suetsugu H, Liu L, Kim K, Yin X, Bang SY, Cui Y, Lee HS, Shoda H, Zhang X, Bae SC, Terao C, Yamamoto K, Okamura T, Ishigaki K (co-corresponding author), Fujio K.
  "Distinct transcriptome architectures underlying lupus establishment and exacerbation."
  Cell. 185(18):3375-3389.e21 (2022)
• 4. *Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price AL, Lecca L, Murray MB, Moody DB, Raychaudhuri S.
  "Single-cell eQTL models reveal dynamic T cell state dependence of disease loci."
  Nature. 606(7912):120-128 (2022)
• 5. Yamaguchi K, Ishigaki K, Suzuki A, Tsuchida Y, Tsuchiya H, Sumitomo S, Nagafuchi Y, Miya F, Tsunoda T, Shoda H, Fujio K, Yamamoto K, Kochi Y.
  "Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci."
  Nature Communications. 13(1):4659 (2022)
• 6. Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T, Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y.
  "Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases."
  Nature Genetics. 52(7): 669-679 (2020)
• 7. *Amariuta T, Ishigaki K (co-first author), Sugishita H, Ohta T, Koido M, Dey KK, Matsuda K, Murakami Y, Price AL, Kawakami E, Terao C, Raychaudhuri S.
  "Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements."
  Nature Genetics. 52(12): 1346-1354 (2020)
• 8. Akiyama M, Ishigaki K, Sakaue S, Momozawa Y, Horikoshi M, Hirata M, Matsuda K, Ikegawa S, Takahashi A, Kanai M, Suzuki S, Matsui D, Naito M, Yamaji T, Iwasaki M, Sawada N, Tanno K, Sasaki M, Hozawa A, Minegishi N, Wakai K, Tsugane S, Shimizu A, Yamamoto M, Okada Y, Murakami Y, Kubo M, Kamatani Y.
  "Characterizing rare and low-frequency height-associated variants in the Japanese population."
  Nature Communications. 27;10(1): 4393 (2019)
• 9. Ishigaki K, Kochi Y, Suzuki A, Tsuchida Y, Tsuchiya H, Sumitomo S, Yamaguchi K, Nagafuchi Y, Nakachi S, Kato R, Sakurai K, Shoda H, Ikari K, Taniguchi A, Yamanaka H, Miya F, Tsunoda T, Okada Y, Momozawa Y, Kamatani Y, Yamada R, Kubo M, Fujio K, Yamamoto K.
  "Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis."
  Nature Genetics. 49(7):1120-1125 (2017)
• 10. *Ishigaki K, Shoda H, Kochi Y, Yasui T, Kadono Y, Tanaka S, Fujio K, Yamamoto K.
  "Quantitative and qualitative characterization of expanded CD4+ T cell clones in rheumatoid arthritis patients."
  Scientific Reports. 6;5:12937 (2015)

研究成果（プレスリリース）

• 

  2022年11月10日
  国際ゲノム解析により関節リウマチの遺伝的背景を解明

• 

  2022年8月23日
  全身性エリテマトーデスの病態解明へ

• 

  2022年3月25日
  自己免疫疾患の最大のリスク因子の機能を解明

• 

  2022年2月18日
  制御性T細胞の新しいマーカーを発見

• 

  2020年6月9日
  疾患発症に関わる日本人の遺伝的特徴の解明

• 

  2017年5月30日
  免疫機能の個人差に関わる遺伝子カタログを作成

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